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. 2017 Jul 18;7:5777. doi: 10.1038/s41598-017-05666-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Superposition of PPARγ/BA and PPARγ/rosiglitazone complexes. Superposition of the crystal structures of the PPARγ/BA (yellow) and PPARγ/rosiglitazone (pdb code 2PRG) (cyan) complexes. The F363 side-chain in gauche conformation (cyan) would sterically clash (black dashed lines) with a methyl group of BA. The gauche* conformation of F363 allows vdW interactions (ranging from 3.3 to 3.7 Å) with hydrophobic residues on H11 (red dashed lines).