Table 1.
Physiological characteristics of Hfe-deficient mice at 1, 5 and 12 months of age.
| N | 1-month | 5-month | 12-month | ||||
|---|---|---|---|---|---|---|---|
| Hfe +/+ | Hfe −/− | Hfe +/+ | Hfe −/− | Hfe +/+ | Hfe −/− | ||
| Body weight† (g) | 8–12 | 14.5 (0.4) | 15.6 (0.3) | 27.4 (0.5) | 26.6 (0.5) | 34.4 (1.3) | 33.4 (0.4) |
| Heart weight†,#,^ (g) | 8–12 | 0.081 (0.002) | 0.079 (0.001) | 0.124 (0.003) | 0.135 (0.003) | 0.162 (0.009) | 0.187* (0.005) |
| Liver weight†,# (g) | 8–12 | 0.62 (0.04) | 0.73 (0.02) | 1.03 (0.05) | 0.98 (0.03) | 1.10 (0.06) | 1.25* (0.02) |
| Heart/Body weight†,^ (%) | 8–12 | 0.56 (0.02) | 0.51* (0.01) | 0.45 (0.01) | 0.51* (0.01) | 0.49 (0.02) | 0.56* (0.01) |
| Liver/Body weight†,# (%) | 8–12 | 4.26 (0.19) | 4.68* (0.10) | 3.77 (0.15) | 3.67 (0.10) | 3.20 (0.15) | 3.76* (0.08) |
Data are presented as the means (SEM). Two-way ANOVA was employed to assess the main effects (age and Hfe gene) as well as interaction effects (age x Hfe gene), followed by the Tukey’s post-hoc analysis for pairwise comparisons (Systat; version 13).
†p < 0.05, age effect.
#p < 0.05, Hfe effect.
^p < 0.05, age x Hfe effect.
*p < 0.05, Hfe −/− vs. age-matched Hfe +/+ mice.