Table 1.
Rog | Rog-A | Rog-μ | Rog-μA | |
EC50 (nM spiradoline) | ||||
Acute activation | 0.41 ± 0.08 | 0.41 ± 0.15 | 0.42 ± 0.23 | 0.50 ± 0.22 |
1 nM spiradoline pretreatment | 4.32 ± 1.96 | 0.42 ± 0.21 | 2.05 ± 0.03 | > 13.44 ± 5.41 |
% Inhibition | ||||
Acute activation | 64.4 ± 4.8 | 56.1 ± 5.1 | 58.0 ± 0.9 | 64.1 ± 4.8 |
1 nM spiradoline pretreatment | 55.7 ± 3.7 | 53.3 ± 0.9 | 43.6 ± 1.5 | 51.5 ± 6.0 |
Values are mean ± SEM for 3–8 experiments for each condition.