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Local administration of CM enhances bone formation: newly formed bone and cartilage were assessed by H&E (A–C) and safranin O–fast green (D, E, F) staining (n = 5). The CM–Hyp group showed a significantly higher bone‐formation area compared with the control group at day 27 (G); there were no significant differences in the three groups in cartilage formation areas on day 27. Bar = 100 µm; data represent mean ± SD; *p < 0.05. [Colour figure can be viewed at wileyonlinelibrary.com]
