Figure 1.

(a) The human cortex develops and grows primarily from two populations of neural stem cells—radial glia [RG; light purple soma with dark purple nucleus positioned near the ventricle in the ventricular zone (VZ)] and outer radial glia [oRG; dark purple soma with light purple nucleus more basally located in the subventricular zone (SVZ)]. These cell types undergo self‐renewing asymmetric divisions, giving rise to either transit amplifying (intermediate progenitor) cells (dark purple) or postmitotic migratory neurons. (b) ZIKV preferentially targets proliferating neural cells including RG, oRG, and neural crest cells. It is likely that a combination of viral‐triggered apoptosis (left arrows) and precocious differentiation (right arrows) contribute to ZIKV‐liked microcephaly. Candidate receptors for Zika virions entry include a number of phosphotidylserine receptors (e.g., AXL, Mer, Tyro3, and TIM1) and are symbolized with a basic domain structure including Ig‐repeats (gray boxes) and kinase domains (green ovals). (Reprinted with permission from 60. Copyright 2016 The American Association for the Advancement of Science)