Table 1.
Genes Disrupted by Both Zika Virus and Microcephaly
| Gene | Proposed Gene Product Function |
|---|---|
| CDK5RAP2 (CDK5 regulatory subunit‐associated protein 2) | Centrosome protein, localizes to centrosome during mitosis31 |
| MCPH1 (MICROCEPHALIN) | G2/M checkpoint regulator32 |
| CASC5 (cancer susceptibility candidate 5) | Formation of kinetochore‐microtubule attachments, chromosome segregation33 |
| WDR62 (WD repeat‐containing protein 62) | Regulation of brain development, localizes to the nucleus and centrosome during mitosis34 |
| ASPM (abnormal spindle‐like microcephaly‐associated protein) | Regulation of mitotic spindle in neuroprogenitor cells35 |
| CENPJ/CPAP (centromere protein J) | Regulation of centrosome integrity and spindle morphology36 |
| STIL (SCL/TAL1‐interrupting locus) | Regulation of mitotic spindle checkpoint37 |
| CEP135 (centrosome protein of 135 kDa) | Maintains structure and organization of the centrosome38 |
| CEP152 (centrosome protein of 152 kDa) | Localizes to centrioles, involved in cell progression through mitosis39 |
| ZNF335 (zinc finger protein 335) | Controls neural progenitor self‐renewal, neurogenesis, and neuronal differentiation40 |
| PHC1 (polyhomeotic‐like protein 1) | Involved in chromatin remodeling/cell cycle regulation41 |
| CDK6 (cyclin‐depenent kinase 6)a | Associates with centrosome during mitosis and regulates centrosome number42 |
a
The only microcephaly‐linked gene with expression unchanged by ZIKV infection of animals or cerebral organoids.