Table 3.
Matching estimated odds ratios and 95% confidence interval for associations between antidepressant use during pregnancy and autism spectrum disorder (ASD)
| Outcome | Propensity score matched analysis* | Sibling matched analysis† | |||
|---|---|---|---|---|---|
| Exposed/unexposed | OR (95% CI) | Affected sibling sets/exposed | OR (95% CI) | ||
| ASD | 1608/4818 | 1.68 (1.23 to 2.30) | 3038/66 | 1.36 (0.84 to 2.20) | |
| ASD without intellectual disability | 1601/4801 | 1.76 (1.26 to 2.46) | 2408/60 | 1.57 (0.92 to 2.66) | |
| ASD with intellectual disability | 1552/4721 | 1.25 (0.52 to 3.03) | 630/6 | 0.78 (0.24 to 2.54) | |
*Propensity score matched estimates of associations of antidepressant use during pregnancy and ASD in children exposed prenatally to antidepressants compared with children exposed to maternal psychiatric disorder but no antidepressants.
†Outcome discordant sibling matched estimates for associations of antidepressant use during pregnancy and ASD. Conditional logistic regression models adjusted for sex, parity, and birth year.