TABLE 1 .
MICs of AcrB substrates for SL1344 and acrB mutants
| Strain | MIC (µg/ml) of substratea: |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACR | ETBR | CIP | NAL | CHL | TET | NOV | FUS | ATM | CAZ | CTX | ERY | OX | MIN | |
| SL1344 | 512 | >2,048 | 0.030 | 4 | 8 | 2 | 512 | 2,048 | 0.50 | 1 | 0.500 | 256 | 512 | 2 |
| ΔacrB mutant | 64 | 32 | 0.008 | 1 | 2 | 0.5 | 8 | 32 | 0.12 | 0.25 | <0.008 | 8 | 16 | 0.25 |
| AcrB D408A | 32 | 32 | 0.008 | 1 | 2 | 0.5 | 8 | 16 | 0.12 | 0.25 | <0.008 | 8 | 16 | 0.25 |
a
Abbreviations: ACR, acriflavine; ETBR, ethidium bromide; CIP, ciprofloxacin; NAL, nalidixic acid; CHL, chloramphenicol; TET, tetracycline; NOV, novobiocin; FUS, fusidic acid; ATM, aztreonam; CAZ, ceftazidime; CTX, cefoxitin; ERY, erythromycin; OX, oxacillin; MIN, minocycline. Mode values from four experiments are shown.