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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 May 17;328:54–59. doi: 10.1016/j.taap.2017.05.018

Figure 3.

Figure 3

Effect of VWF deficiency on liver fibrosis after chronic CCl4 challenge. Female wild-type (WT) and VWF−/− mice were given carbon tetrachloride (CCl4) dissolved to 10% in corn oil (10 ml/kg, ip) twice weekly for 6 weeks. (A–B) Representative photomicrographs and quantification of sirius red birefringence in liver sections visualized under polarized light. (C–D) Representative photomicrographs and quantification of type I collagen immunofluorescent staining of frozen liver sections. Data are expressed as mean + SEM. For panel B, N=5–8 mice per group for vehicle-treated mice and 16–20 for CCl4-challenged mice. N=3 mice per group for panel D. *Significantly different from vehicle-treated mice of the same genotype. #Significantly different from CCl4-challenged WT mice. P<0.05.