Table 2.
Top 20 Genes Down-Regulated in Human Pulmonary Artery Endothelial Cells after E–Twenty Six–Related Gene and Friend Leukemia Integration 1 Transcription Factor Knockdown
| Gene Symbol | Gene Name | Fold Change |
|---|---|---|
| FABP4 | Fatty acid binding protein 4, adipocyte | −42.42 |
| LYVE1 | Lymphatic vessel endothelial hyaluronan receptor 1 | −18.04 |
| RGS7BP | Regulator of G-protein signaling 7 binding protein | −15.94 |
| DLL4 | Delta-like 4 (Drosophila) | −12.06 |
| CHST1 | Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | −11.52 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | −11.09 |
| TSPAN18 | Tetraspanin 18 | −10.47 |
| ACE | Angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | −9.65 |
| C15orf54 | Chromosome 15 open reading frame 54 | −9.62 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | −9.02 |
| APLN | Apelin | −8.80 |
| CXorf36 | Chromosome X open reading frame 36 | −8.48 |
| PLEKHG1 | Pleckstrin homology domain containing, family G (with rhogef domain) member 1 | −8.37 |
| CYTL1 | Cytokine-like 1 | −8.37 |
| GDPD5 | Glycerophosphodiester phosphodiesterase domain containing 5 | −8.14 |
| PLXNA4 | Plexin A4 | −7.85 |
| CPNE5 | Copine V | −7.28 |
| GPR116 | G protein–coupled receptor 116 | −7.25 |
| TRAC | T cell receptor α constant | −7.07 |
| ADAMTS18 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | −6.88 |
Definition of abbreviation: ADAM, a disintegrin and metalloprotease.