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. 2017 Jul;57(1):47–58. doi: 10.1165/rcmb.2016-0328OC

Figure 1.

Figure 1.

Different strains and genetic models display varying degrees of emphysema upon 6 months of cigarette smoke (CS) exposure. (A) Mean chord length (MCL) varies among strain and targeted genetic models after 6 months of CS exposure. Baseline controls (exposed to filtered air) of C57BL6/J, Hhip+/−, and Fam13a−/− do not show difference in MCL, but NZWLac/J is significantly lower (ANOVA, Tukey’s honest significant difference post hoc test, ##P < 0.001). NZWLac/J and Fam13a−/−, strain and genetic models resistant to CS-induced emphysema, show no difference in MCL between baseline and CS groups (P > 0.05, t test). CS and baseline groups of C57BL6/J and Hhip+/− differ in MCL (*P < 0.01, t test), and the CS groups of C57BL6/J and Hhip+/− differ in MCL as well (**P < 0.001, t test). (B) Lung histology sections from NZW/LacJ and C57BL/6J mice exposed to room air or CS. There is minimal airspace enlargement in NZW/LacJ mice compared with C57BL/6J mice. Original magnification: ×200.