Table 2.

Expression of Xenobiotic Metabolism and Nuclear Erythroid 2-Related Factor 2-Mediated Oxidative Stress Response Genes in Hhip^+/−, C57BL/6, Fam13a^−/− Mice in Response to 6 Months of Cigarette Smoke Exposure

Pathways	Hhip+/−		C57BL/6		Fam13a−/−
	Gene	Log FC	Gene	LogFC	Gene	LogFC
Xenobiotic metabolism signaling	Aldh3a1	1.554	Aldh3a1	1.992	Aldh3a1	1.737
	Cyp1a1	0.171	Cyp1a1	0.633
	Cyp1b1	1.211	Cyp1b1	2.257	Cyp1b1	0.957
					Gsta3	0.339
	Gstp1	0.837	Gstp1	0.76	Gstp1	1.077
			Gsto1	0.495	Gsto1	0.948
	Nqo1	1.215	Nqo1	1.131	Nqo1	1.24
					Nqo2	0.339
	Ugt1a6	0.609	Ugt1a6	0.473	Ugt1a6	1.02
	Ugt1a7	0.714	Ugt1a7	0.569	Ugt1a7	1.07
	Pik3r3	0.213	Ahrr	0.207	Ces1 g	0.099
					Mapk13	0.476
					Mgst1	0.484
					Mgst2	0.553
					Smox	0.343
					Sra1	0.253
					Sult1d1	0.839
Nrf2-mediated oxidative stress response	Gpx2	1.007	Gpx2	1.088	Gpx2	1.321
	Gstp1	0.837	Gstp1	0.76	Gstp1	1.077
	Nqo1	1.215	Nqo1	1.131	Nqo1	1.24
	Pik3r3	0.213			Nqo2	0.339
			Gsto1	0.495	Gsto1	0.948
			Cbr1	0.456	Cbr1	0.637
			Gclm	0.881	Actc1	0.735
					Akr7a2	0.212
					Cdc34	0.215
					Gsta3	0.339
					Mgst1	0.484
					Mgst2	0.553

Definition of abbreviations: FC, fold change; Nrf2, nuclear erythroid 2-related factor 2.

Pathway analysis was performed using ingenuity pathway analysis.