Table 4.
Gene Expression Pattern in Resistant Phenotype NZW/LacJ and Fam13a−/− Mice
| Group | Air |
CS |
||
|---|---|---|---|---|
| Up-Regulated | Down-Regulated | Up-Regulated | Down-Regulated | |
| NZW/LacJ versus C57BL/6 | 99 | 141 | 0 | 0 |
| RhoA signaling | Superpathway of cholesterol biosynthesis | |||
| PCP pathway | Ketolysis | |||
| LPS/IL-1–mediated inhibition of RXR function | Systemic lupus erythematosus signaling | |||
| Autophagy | Ketogenesis | |||
| Hypoxia signaling in the cardiovascular system | ATM signaling | |||
| Fam13a−/− versus C57BL/6 | 0 | 0 | 24 | 42 |
| Melatonin degradation I | Ephrin receptor signaling | |||
| LPS/IL-1–mediated inhibition of RXR function | Bladder cancer signaling | |||
| Superpathway of melatonin degradation | VEGF family ligand-receptor interactions | |||
| S-adenosyl-L-methionine biosynthesis | VEGF signaling | |||
| Embryonic stem cell differentiation into cardiac lineages | Leukotriene biosynthesis | |||
Definition of abbreviations: ATM, ataxia telangiectasis mutated protein; CS, cigarette smoke; PCP, planar cell polarity; RXR, retinoid X receptor; VEGF, vascular endothelial growth factor.
The number of differentially expressed genes and the top five pathways in CS-exposed NZW/LacJ mice and Fam13a−/− mice compared to C57BL/6 are shown (false discovery rate < 0.2). Pathway analysis was performed using Ingenuity Pathway Analysis software. For complete list of differentially expressed genes, please refer to Tables E1 and E2 in the online supplement.