Table 5.

Shared Genes among Human Chronic Obstructive Pulmonary Disease, Emphysema, and Murine Models

Comparison Group (No. of Genes)	COPD Genes (1,003)	Emphysema
		Perc15 (1,433)	LAA950 (1,740)
WT CS versus Hhip+/− CS (343)	14	23	32
WT CS versus Fam13a−/− CS (66)	5	5	5
Fam13a−/− versus Hhip+/− CS (1,010)	36	55	74

Definition of abbreviations: COPD, chronic obstructive pulmonary disease; CS, cigarette smoke; LAA950, low attenuation areas at −950 Hounsfield units on chest computed tomography scans; Perc15, 15th percentile of the lung density histogram on chest computed tomography scans; WT, wild-type C57BL/6J mice.

Number of shared orthologous genes between mice models and human subjects, at false discovery rate less than 0.2. See Table E3 for the individual gene lists.