Table 4.
Genetic Risk Score Loci
| Gene | SNP Identifier |
|---|---|
| CHRNA3 | rs12914385 |
| RAB4B/EGLN2/MIA/CYP2A6 | rs7937 |
| RIN3 | rs754388 |
| TGFB2 | rs4846480 |
| MMP12 | rs626750 |
| HHIP | rs13141641 |
| FAM13A | rs4416442 |
| PTCH1 | rs16909898 |
| C10orf11 | rs11001819 |
| HTR4 | rs11168048 |
| DNER | rs7594321 |
| HDAC4-FLJ43879 | rs12477314 |
| MFAP2 | rs2284746 |
| ARMC2 | rs2798641 |
| LRP1 | rs11172113 |
| RARB | rs1529672 |
| GSTCD/INTS12/NPNT | rs10516526 |
| NCR3-AIF1 | rs2857595 |
| MECOM/EVI1 | rs1344555 |
| AGER/PPT2 | rs2070600 |
| ZKSCAN3 | rs6903823 |
| SPATA9-RHOBTB3 | rs153916 |
| MMP15 | rs12447804 |
| HLA-DQB1 | rs7765379 |
| KCNJ2/CASC17 | rs11654749 |
| GPR126 | rs3817928 |
| TGFB2-LYPLAL1 | rs993925 |
| CDC123 | rs7068966 |
| KCNE2-LINC00310/C21orf82 | rs9978142 |
| THSD4 | rs12899618 |
Definition of abbreviations: COPD7, genetic risk score composed of seven COPD risk SNPs (ranging from 0 to 14 scoring alleles); LUNG30, genetic risk score compsed of thirty lung function associated risk SNPs (ranging from 0 to 60 scoring alleles); SNP, single-nucleotide polymorphism.
Genetic risk scores were composed using previous chronic obstructive pulmonary disease (COPD) and lung function–associated loci. The LUNG30 score included all of the loci listed in the above table; the COPD7 score included only those in the bold. Loci names are based on previously reported SNP associations annotated to the nearest gene or region.