Table 5.

Genetic Risk Scores: Lung Function in International Chronic Obstructive Pulmonary Disease Genetics Network

Risk Score	Unadjusted FEV1 % per Risk Allele (95% CI)	P Value	Adjusted FEV1 % per Risk Allele (95% CI)	P Value
COPD7	−2.02 (−1.34 to −2.70)	6.74 × 10−9	−1.86 (−1.24 to −2.50)	7.90 × 10−9
LUNG30	−1.18 (−0.83 to −1.53)	4.70 × 10−11	−1.10 (−0.78 to −1.43)	3.78 × 10−11

Definition of abbreviations: CI, confidence interval; COPD7, genetic risk score composed of seven COPD risk SNPs (ranging from 0 to 14 scoring alleles); LUNG30, genetic risk score composed of thirty lung function associated risk SNPs (ranging from 0 to 60 scoring alleles); SNP, single-nucleotide polymorphism.

For each risk score (chronic obstructive pulmonary disease [COPD] 7 and LUNG30), the linear mixed-model coefficient is presented with 95% CI and P value. Final model included adjustment for age, pack-years, familial correlation, and principal components for genetic ancestry, whereas the unadjusted model was not adjusted for age and pack-years.