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. 2017 Jun;56(6):708–715. doi: 10.1165/rcmb.2016-0154OC

Figure 5.

Figure 5.

IL-17A blockade is associated with enrichment of T-helper cell type 17 and IL-17A+ γδ T cells. As in Figures 1–4, lungs were analyzed on Day 21 after transplant. Untreated or isotype antibody–treated allografts were used as control allografts. (A) Dot plots with a frequency of IL-17A+ CD4+ T cells of lymphocytes in the lung allografts. (B) Frequency and absolute number of IL-17A+ CD4+ T cells in the lung allografts. (C) Dot plots showing frequency of IL-17A+γδ T cells on gated lymphocytes in the lung allografts. (D) Frequency and absolute number of IL-17A+ γδ T cells in the lung allografts. The absolute number of cells has been normalized to the weight of the lung. In A and B, n = 11 (control and anti–IL-17A); in C and D, n = 5 (control), n = 11 (anti–IL-17A); unpaired t test or Mann–Whitney U test was used for comparison; *P < 0.05. Data are representative of two independent experiments.