Table 4.
Top 10 REACTOME Pathways Enriched in Proteins Up-Regulated in Apical Secretome by DA Exposure
| Pathway Name | No. of Proteins | No. of Proteins in Pathway | P value | FDR | Proteins Identified |
|---|---|---|---|---|---|
| Degradation of the extracellular matrix | 8 | 135 | 1.28E-07 | 5.43E-05 | LAMC2; CADH1; LAMA3; MMP10; LAMB3; PGBM; MMP9; TIMP1 |
| Extracellular matrix organization | 10 | 291 | 4.37E-07 | 7.68E-05 | LAMC2; CADH1; CEAM6; LAMA3; MMP10; LAMB3; PGBM; MMP9; TIMP1; TENA |
| Apoptosis | 8 | 165 | 5.80E-07 | 7.68E-05 | CADH1; PSA3; DSG2; CD14; PSB6; PSA7; PSB5; SPTN1 |
| Programmed cell death | 8 | 170 | 7.24E-07 | 7.68E-05 | CADH1; PSA3; DSG2; CD14; PSB6; PSA7; PSB5; SPTN1 |
| Cell-cell communication | 7 | 139 | 2.48E-06 | 2.08E-04 | LAMC2; CADH1; LAMA3; LAMB3; SPTB2; SPTN1; FLNA |
| Non-integrin membrane–ECM interactions | 5 | 59 | 6.51E-06 | 4.56E-04 | LAMC2; LAMA3; LAMB3; PGBM; TENA |
| Laminin interactions | 4 | 30 | 1.01E-05 | 6.08E-04 | LAMC2; LAMA3; LAMB3; PGBM |
| Type I hemidesmosome assembly | 3 | 11 | 1.73E-05 | 9.15E-04 | LAMC2; LAMA3; LAMB3 |
| TCF-dependent signaling in response to WNT | 7 | 198 | 2.44E-05 | 1.00E-03 | PSA3; H2B1M; H4; PSB6; PSA7; DKK1; PSB5 |
| Anchoring fibril formation | 3 | 15 | 4.32E-05 | 1.00E-03 | LAMC2; LAMA3; LAMB3 |
| Cell junction organization | 5 | 90 | 4.86E-05 | 1.00E-03 | LAMC2; CADH1; LAMA3; LAMB3; FLNA |
Definition of abbreviations: DA, diacetyl; ECM, extracellular matrix; FDR, false discovery rate; TCF, T-cell factor.