Table 5.
Top 10 REACTOME Pathways Enriched in Proteins Down-Regulated in Apical by DA Exposure
| Pathway name | No. of Proteins | No. of Proteins in Pathway | P value | FDR | Proteins Identified |
|---|---|---|---|---|---|
| Regulation of complement cascade | 3 | 27 | 9.74E-05 | 9.74E-03 | CFAB; CD59; CO4A |
| Activation of C3 and C5 | 2 | 7 | 2.49E-04 | 1.25E-02 | CFAB; CO4A |
| Lipid digestion, mobilization, and transport | 3* | 70 | 1.54E-03 | 4.95E-02 | PLTP; CEL |
| HDL-mediated lipid transport | 2* | 20 | 1.98E-03 | 4.95E-02 | PLTP |
| Complement cascade | 4 | 201 | 4.00E-03 | 5.49E-02 | CLUS; CFAB; CD59; CO4A |
| Platelet degranulation | 3 | 105 | 4.82E-03 | 5.49E-02 | A1AT; CLUS; AACT |
| Lipoprotein metabolism | 2* | 32 | 4.95E-03 | 5.49E-02 | PLTP |
| Cargo concentration in the ER | 2 | 33 | 5.25E-03 | 5.49E-02 | A1AT; CD59 |
| Response to elevated platelet cytosolic Ca2+ | 3 | 110 | 5.49E-03 | 5.49E-02 | A1AT; CLUS; AACT |
| Utilization of ketone bodies | 1 | 3 | 9.75E-03 | 8.77E-02 | THIL |
| Lysosomal oligosaccharide catabolism | 1 | 4 | 1.30E-02 | 1.03E-01 | MANBA |
Definition of abbreviations: DA, diacetyl; ER, endoplasmic reticulum; FDR, false discovery rate; HDL, high-density lipoprotein; NB, nota bene.
*
NB: PLTP has two natural variants.