Table 7.
Top 10 REACTOME Pathways Enriched in Proteins Down-Regulated in Basolateral by DA Exposure
| Pathway Name | No. of Proteins | No. of Proteins in Pathway | P value | FDR | Proteins Identified |
|---|---|---|---|---|---|
| PTK6 promotes HIF1A stabilization | 2 | 6 | 1.49E-04 | 4.54E-02 | GPNMB; EGFR |
| Synthesis of IP2, IP, and Ins in the cytosol | 2 | 11 | 4.97E-04 | 4.83E-02 | IMPA2; INO1 |
| Assembly of collagen fibrils and other multimeric structures | 3 | 55 | 5.71E-04 | 4.83E-02 | CO5A2; CO7A1; CO1A1 |
| Collagen degradation | 3 | 63 | 8.45E-04 | 4.83E-02 | CO5A2; CO7A1; CO1A1 |
| Anchoring fibril formation | 2 | 15 | 9.18E-04 | 4.83E-02 | CO7A1; CO1A1 |
| Collagen biosynthesis and modifying enzymes | 3 | 66 | 9.66E-04 | 4.83E-02 | CO5A2; CO7A1; CO1A1 |
| Integrin cell–surface interactions | 3 | 86 | 2.06E-03 | 8.34E-02 | CO5A2; CO7A1; CO1A1 |
| Collagen formation | 3 | 88 | 2.19E-03 | 8.34E-02 | CO5A2; CO7A1; CO1A1 |
| Syndecan interactions | 2 | 27 | 2.91E-03 | 9.60E-02 | CO5A2; CO1A1 |
| Signaling by overexpressed wild-type EGFR in cancer | 1 | 2 | 5.88E-03 | 1.59E-01 | EGFR |
Definition of abbreviations: DA, diacetyl; EGFR, epidermal growth factor receptor; FDR, false discovery rate; HIF1A, hypoxia inducible factor 1A; Ins, inositol; IP, inositol phosphate; PTK6, protein tyrosine kinase 6.