Table 2.

Sequential Adjusted Models to Explain Temporal Trends of AKI Requiring Dialysis

	Unadjusted Odds Ratio/year (95% CI)	P	Adjusted Odds Ratio/year (95% CI) Model 1	P	Adjusted Odds Ratio/year (95% CI) Model 2	P
Heart transplant	1.05 (1.02 - 1.09)	<0.01	1.03 (1 - 1.06)	0.04	1.01 (0.9 - 1.05)	0.39
Liver transplant	1.06 (1.04 - 1.08)	<0.01	1.04 (1.01 - 1.06)	<0.01	1.024 (0.99 - 1.05)	0.09

Model 1: Adjusted for changes in age, sex and race

Model 2: Model 1 + Changes in comorbidities (HIV status, diabetes, hypertension, CKD, sepsis, heart failure, chronic liver diseases, liver cancer) and procedures (cardiac catheterizations and mechanical ventilation)