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Comparison of apoptosis induced by DZNep in chondrosarcomas cultured in 2D and 3D cultures
| Apoptotic cell fraction | p-value (DZNep Vs control) | p-value (DZNep 3D Vs DZNep 2D) | ||
|---|---|---|---|---|
| Control | DZNep | |||
| 2D | 0.73 ± 0.3% | 29.6 ± 1.4% | 0.001 | |
| 3D | 21.7 ± 1.4% | 86.8 ± 1.7% | 0.001 | 0.001 |
Chondrosarcoma cells were cultured in monolayer (2D) or embedded in alginate (3D). Then, cells were treated with 1 μM DZNep. Fourteen days later, apoptosis was assayed. Values represent means ± SEM of 3 experiments
