Table 3.
Cheek measurements
| NSS |
SS |
AR |
AD |
SS vs. NSS | SS vs. AD | SS vs. AR | NSS vs. AD | NSS vs. AR | AD vs. AR | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | median (range) | n | median (range) | n | median (range) | n | median (range) | |||||||
| Biophysical measurements | ||||||||||||||
| TEWL, g/m2/h | 30 | 23.8 (12.8 – 40.8) | 28 | 22.7 (10.2 – 37.5) | 27 | 23.0 (13.1 – 40.9) | 11 | 23.2 (15.3 – 42.7) | ns | ns | ns | ns | ns | ns |
| SC hydration, AU | 30 | 37.9 (9.0 – 62.3) | 28 | 30.7 (7.3 – 54.4) | 27 | 29.8 (16.2 – 59.0) | 11 | 36.7 (18.5 – 88.2) | ns | ns | ns | ns | ns | ns |
| Sebum, AU | 30 | 48.3 (0.3 – 290.0) | 28 | 50.8 (0.0 – 209.3) | 27 | 46.7 (0.0 – 373.0) | 11 | 31.0 (4.3 – 215.7) | ns | ns | ns | ns | ns | ns |
| CRS parameters | ||||||||||||||
| SC thickness, µm | 30 | 14.1 (11.6 – 17.3) | 28 | 14.0 (10.8 – 21.5) | 27 | 14.3 (12.0 – 19.1) | 11 | 13.7 (12.6 – 15.9) | ns | ns | ns | ns | ns | ns |
| AUC water 4-SC, AU | 30 | 516.9 (417.7 – 639.1) | 28 | 507.5 (393.4 – 780.4) | 27 | 512.1 (425.5 – 777.3) | 11 | 482.9 (433.9 – 623.5) | ns | ns | ns | ns | ns | ns |
| Average NMF 4 – 8 µm, AU | 30 | 0.9 (0.5 – 1.3) | 28 | 0.8 (0.5 – 1.5) | 27 | 0.8 (0.4 – 1.3) | 11 | 0.8 (0.4 – 1.0) | ns | ns | ns | 0.091 | ns | ns |
| Average Cer 4 – 8 µm, AU | 30 | 82.2 (47.5 – 142.9) | 28 | 72.1 (45.1 – 155.1) | 27 | 72.0 (35.4 – 143.2) | 11 | 66.3 (39.2 – 92.0) | 0.077 | ns | ns | 0.097 | ns | ns |
AD, atopic dermatitis; AR, allergic rhinoconjunctivitis; AU, arbitrary units; AUC, area under the curve; Cer, ceramides/fatty acids; CRS, confocal Raman microspectroscopy; NMF, natural moisturizing factor; ns, no statistically significant difference; NSS, non-sensitive skin; SC, stratum corneum; SS, sensitive skin; TEWL, transepidermal water loss.