Table 4.
Thenar measurements
| NSS |
SS |
AR |
AD |
SS vs. NSS | SS vs. AD | SS vs. AR | NSS vs. AD | NSS vs. AR | AD vs. AR | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | median (range) | n | median (range) | n | median (range) | n | median (range) | |||||||
| Biophysical measurements | ||||||||||||||
| TEWL, g/m2/h | 29 | 39.6 (21.8 – 80.6) | 28 | 29.9 (19.4 – 67.8) | 27 | 32.6 (16.5 – 58.6) | 11 | 39.9 (21.1 – 60.8) | 0.016 | 0.058 | ns | ns | 0.050 | 0.071 |
| SC hydration, AU | 29 | 32.8 (15.2 – 82.2) | 28 | 27.0 (9.1 – 42.5) | 27 | 33.0 (15.3 – 47.9) | 11 | 29.9 (13.9 – 56.3) | ns | ns | ns | ns | ns | ns |
| CRS parameters SC thickness, µm | 29 | 97.6 (57.1 – 159.1) | 28 | 97.4 (40.1 – 159.6) | 27 | 111.7 (43.9 – 149.7) | 11 | 96.7 (41.4 – 144.2) | ns | ns | ns | ns | ns | ns |
| AUC water 10-SC, AU | 29 | 3,702.2 (2,176.8 – 6,659.5) | 28 | 3,741.9 (1,401.8 – 6,642.8) | 27 | 4,140.7 (1,629.3 – 5,609.8) | 11 | 3,840.5 (1,447.8 – 5,263.0) | ns | ns | ns | ns | ns | ns |
| Average NMF 10 – 50 µm, AU | 29 | 1.7 (1.1 – 2.2) | 28 | 1.8 (1.1 – 2.6) | 27 | 1.9 (1.1 – 2.5) | 11 | 1.9 (0.9 – 2.0) | ns | ns | ns | ns | 0.076 | ns |
AD, atopic dermatitis; AR, allergic rhinoconjunctivitis; AU, arbitrary units; AUC, area under the curve; Cer, ceramides/fatty acids; CRS, confocal Raman microspectroscopy; NMF, natural moisturizing factor; ns, no statistically significant difference; NSS, non-sensitive skin; SC, stratum corneum; SS, sensitive skin; TEWL, transepidermal water loss.