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. Author manuscript; available in PMC: 2018 Mar 2.
Published in final edited form as: Chembiochem. 2017 Jan 25;18(5):466–469. doi: 10.1002/cbic.201600624

Figure 1.

Figure 1

Schematic showing the role of UvrD in bacterial NER. During damage detection, UvrA and UvrB proteins bind at the site of damaged DNA. Once UvrB is loaded at the site of damage during the verification step, UvrA dissociates and UvrC is recruited and produces two incisions on the damaged strand both 5′ and 3′to the damaged nucleotide. The dual action of UvrD and Pol1 are necessary to remove the damaged oligonucleotide and carry out repair synthesis using the complementary strand as a template. DNA ligase seals the newly made repair patch.