. Author manuscript; available in PMC: 2018 Jan 27.

Published in final edited form as: J Nat Prod. 2017 Jan 18;80(1):220–224. doi: 10.1021/acs.jnatprod.6b01153

Table 1.

Antiproliferative Activities of the Selected Pavine Alkaloids

	human cell lines^a/IC₅₀ (µM)^b

alkaloid	A549	MDA-MB- 231	MCF-7	KB	KB-VIN
1	0.064	0.264	0.413	0.228	0.241
2	3.981	5.707	7.421	5.488	5.907
3	8.709	26.13	26.56	17.03	19.80
4	29.26	41.01	>40	35.50	>40
5	>40	>40	>40	>40	>40
PXL (nM)	6.20	8.82	10.40	6.27	1926

A549 (lung carcinoma), MDA-MB-231 (triple-negative breast cancer), MCF-7 (estrogen receptor-positive & HER2-negative breast cancer), KB (epidermoid carcinoma of the nasopharynx), KB-VIN (Pgp-overexpressing MDR subline of KB).

Antiproliferative activity as IC₅₀ values for each cell line, the concentration of compound that caused 50% reduction relative to untreated cells determined by the SRB assay.