Table 2.

Unadjusted and Covariate-adjusted Models for Clinical Outcome in Children with Familial DCM or Idiopathic DCM

Outcome	N	Predictor	Hazard Ratio (95% CI)	P Value*
Unadjusted Models
Death	870	Familial DCM vs. Idiopathic DCM	0.64 (0.40–1.02)	0.04/0.06
Transplant	870	Familial DCM vs. Idiopathic DCM	1.02 (0.78–1.32)	0.72/0.91
Death/Transplant	870	Familial DCM vs. Idiopathic DCM	0.85 (0.6–1.1)	0.15
Covariate-Adjusted Models
Death	869	Familial DCM vs. Idiopathic DCM	0.71 (0.44–1.13)	0.14
		Presence of CHF at diagnosis	2.36 (1.34–4.15)	0.003
Transplant	698	Familial DCM vs. Idiopathic DCM	1.05 (0.76–1.44)	0.77
		Age at diagnosis, yr	1.08 (1.06–1.11)	< 0.001
		Presence of CHF at diagnosis	2.88 (1.88–4.43)	< 0.001
		LVEDD z-score at diagnosis	1.20 (1.13–1.27)	< 0.001
Death/Transplant	698	Familial DCM vs. Idiopathic DCM	0.97 (0.74–1.28)	0.85
		Age at diagnosis, yr	1.06 (1.04–1.08)	< 0.001
		Presence of CHF at diagnosis	3.45 (2.37–5.02)	< 0.001
		LVEDD dimension z-score at diagnosis	1.13 (1.08–1.19)	< 0.001

CHF, congestive heart failure; CI, confidence interval; DCM, dilated cardiomyopathy; LVEDD, left ventricular end-diastolic dimension

^*Where 2 p-values are shown, the first is based on cause-specific hazard function and the second is based on the cumulative incidence functions for FDCM vs. IDCM via Fine-Gray subdistribution function. For death alone and transplant alone in adjusted modeling, the p-value is based the Fine-Gray regression. For death/transplant composite, the p-value is derived from the Wald test of the log hazard ratio estimated by Cox proportional hazards regression modeling.