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. 2015 Dec 17;1:15024. doi: 10.1038/npjparkd.2015.24

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Copyright © 2015 Parkinson's Disease Foundation/Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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TH-immunohistochemistry of the substantia nigra of vehicle injection (a) and FN075 injection (b) into the substantia nigra. The depletion of TH-positive neurons is seen ipsilateral to the accelerator injection (left in b). Almost 50% reduction in counts of TH-positive neurons was found in mice injected with the accelerator compared with controls and animals treated with the inhibitor at 3 months after substantia nigra injection (n=6 for vehicle, n=4 for inhibitor, and n=6 for accelerator; c). In contrast to the significant reduction of TH-positive neurons in normal mice, no differences in the number of TH-positive neurons was found in Snca KO mice after injection of FN075 near substantia nigra at 3 months postinjection (n=6 for vehicle and n=6 for accelerator, d). *P<0.05; **P<0.01. Scale bars: (a and b) 100 μm.