Table 1. Baseline demographics and disease characteristics.
| Characteristic | No baseline resting tremor n=196 | Mild baseline resting tremor n=38 | Significant baseline resting tremor n=52 |
|---|---|---|---|
| Mean age, years (s.d.) | 64.7 (9.2) | 60.7 (8.5) | 64.1 (9.7) |
|
Sex, n (%)
| |||
| Male | 112 (57) | 26 (68) | 31 (60) |
| Female | 84 (43) | 12 (32) | 21 (40) |
| Mean PD duration, years (s.d.) | 12.1 (4.7) | 11.6 (6.2) | 13.0 (7.4) |
| Range | 2.8–23.2 | 1.5–34.7 | 3.4–31.3 |
| Mean levodopa dose at baseline, mg/day (s.d.) | 1115 (589)a | 1161 (674) | 1021 (478)b |
| Amantadine use at baseline, n (%) | 61 (31) | 12 (32) | 14 (27) |
| ‘Off’ time, hours/day, mean (s.d.) | 6.62 (2.18) | 6.88 (2.08) | 7.34 (2.98) |
| ‘On’ time with TSD, hours/day, mean (s.d.) | 1.67 (2.14) | 1.88 (2.00) | 1.43 (1.78) |
| ‘On’ time without TSD, hours/day, mean (s.d.) | 7.71 (2.29) | 7.24 (2.72) | 7.23 (2.60) |
| UPDRS Part III Question 20 (resting tremors) total scorec, mean (s.d.) | 0 (0) | 1.69 (0.8) | 5.25 (2.6) |
| UPDRS Part III Question 21 (action tremors) total scored, mean (s.d.) | 0.64 (1.08) | 1.29 (1.16) | 2.37 (1.77) |
| PDQ-39 SI, mean (s.d) | 42.81 (14.86) | 45.30 (13.20) | 43.16 (18.02) |
Abbreviations: PD, Parkinson’s disease; PDQ-39 SI, PD Questionnaire 39 summary index; TSD, troublesome dyskinesia; UPDRS, Unified Parkinson’s Disease Rating Scale.
a
n=192.
b
n=51.
c
Sum of UPDRS Part III Question 20 scores from the five categories (head, upper and lower extremities), with a possible range of 0–20.
d
Sum of UPDRS Part III Question 21 scores from the two categories (left and right hands), with a possible range of 0–8.