Table 6. DBS effects on body weight in patients with PD.
| Author | Year | Outcome measure | Type of study | No. of patients | Main outcome after DBS |
|---|---|---|---|---|---|
| Strowd et al.84 | 2016 | Height, weight and BMI | 2 years retrospective case–control | 69; 35 STN (10 uni, 25 bil) 34 BMT | STN-DBS group: WG mean 2.9 kg versus BMT group mean W loss of 1.8 kg (1.82±6.9 kg). No difference between uni and bil STN. |
| Strowd et al.83 | 2010 | Weight | 2 years retrospective DBS for PD, ET, dystonia | 182 | Mean WG of 1.8 kg at 24 month follow-up in the whole sample. In the PD subpopulation, mean WG of 2.3 kg. |
| Walker et al.88 | 2009 | Weight | 1-year case–control | 39 uni STN 40 BMT | STN DBS (case) mean WG of 4.3 kg compared with controls (BMT). |
| Montaurier et al.87 | 2007 | Body composition Dual X-ray absorptiometry and energy expenditure were measured over 36 h in calorimetric chambers. | 4 months prospective open | 24 | Normalization of energy metabolism after DBS-STN implantation may favor body WG. Men gained primarily fat-free mass. Women gained mainly fat mass. |
| Macia et al.90 | 2004 | Weight and BMI | Case–control | 19 STN 14 BMT | The SNT-DBS group had a significant weight gain (9.7±7 kg) and BMI increase (4.7 kg/m2) vs. control group. |
| Gironell et al.85 | 2002 | Questionnaire about severity and etiology of weight again | 1-year prospective | 27 | Mean WG was 4.7 kg after surgery. Significant correlation between WG and improvement of dyskinesias. Majority of patients referred WG as adverse event. |
Abbreviations: BC, body composition; bil, bilateral; BMI, body mass index; BMT, basal metabolic rate; DBS, deep brain stimulation; ET, essential tremor; PD, Parkinson’s disease; STN, subthalamic nucleus; uni, unilateral; W, weight; WG, weight gain.