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. 2016 Nov 3;2:16020. doi: 10.1038/npjparkd.2016.20

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Copyright © 2016 The Author(s)

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Change from baseline for PD diary measures. Daily totals were normalized to a 16 h waking day and the 3 days before the visit were averaged. ‘On’ time without troublesome dyskinesia is the sum of ‘on’ time without dyskinesia and ‘on’ time with non-troublesome dyskinesia. At baseline, the mean (s.d.) daily hours of PD Symptom Diary measures were: ‘off’ time=7.4 (2.3), ‘on’ time with TSD=1.1 (2.3), and ‘on’ time without TSD=7.5 (2.5). Error bars indicate standard error. P values indicate statistically significant mean change from baseline of *P⩽0.05 and ***P⩽0.001. At baseline, weeks 1–6, and final, the sample size was 29; and at week 8, it was 27 for all the measures. At weeks 10 and 12, the sample size was 28 for ‘on’ time with and without TSD and 27 for ‘off’ time. PD, Parkinson's disease; TSD, troublesome dyskinesia.