. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: J Surg Oncol. 2016 Sep 19;114(5):637–641. doi: 10.1002/jso.24358

Table 7.

Sensitivity analysis; Multivariate analysis of the association between Distance from the Anal Verge and (a) complete pathologic response or (b) complete clinical or pathologic response (OR Odds Ratio, NOM Non operative management, ref Reference)

DTAV	Study Cohort (N = 827)^a	Known treatment interval (N = 338)^a	Study Cohort and NOM (N = 862)^b
DTAV	OR (95% CI)	OR (95% CI)	OR (95% CI)
< 4 cm	1 (ref)^*	1 (ref)^**	1 (ref)^***
4 - 6 cm	2.53 (1.36 - 4.75)	2.31 (0.81 - 6.55)	2.55 (1.46 - 4.44)
6 - 8 cm	2.55 (1.37 - 4.74)	2.25 (0.81 - 6.28)	1.99 (1.13 - 3.49)
8 - 10 cm	1.74 (0.87 - 3.48)	0.64 (0.19 - 2.20)	1.53 (0.82 - 2.85)
> 10 cm	1.29 (0.51 - 3.28)	0.75 (0.16 - 3.55)	1.18 (0.51 - 2.74)

Test for overall effect P = 0.008

^**

Test for overall effect P = 0.027

^***

Test for overall effect P = 0.0054