TABLE III.
ACCI discriminant properties: Mean (95% CI) asthma control, QOL, and spirometric values across ACCI control categories by using ANOVA
| ACCI Mild-intermittent | ACCI Mild-persistent | ACCI Moderate-persistent | ACCI Severe-persistent | P trend | |
|---|---|---|---|---|---|
| Asthma control measures | |||||
| ACT | 20 (19–22) | 18 (18–19) | 15 (14–16) | 12 (11–13) | <.001 |
| ACQ | 1.4 (1.1–1.7) | 2 (1.9–2.1) | 2.7 (2.6–2.9) | 3.4 (3.1–3.6) | <.001 |
| ATAQ | 2.3 (1.9–2.6) | 2.4 (2.1–2.6) | 2.7 (2.5–2.8) | 2.8 (2.6–2.9) | .032 |
| QOL measures | |||||
| m-AQLQ domains | |||||
| Overall | 6.0 (5.5–6.4) | 5.2 (5.0–5.5) | 4.5 (4.3–4.7) | 3.6 (3.3–3.9) | <.001 |
| Symptom | 5.9 (5.4–6.4) | 5.2 (5.0–5.4) | 4.3 (4.1–4.5) | 3.4 (3.1–3.7) | <.001 |
| Activity | 6.6 (6.1–7.0) | 5.6 (5.3–5.9) | 5.0 (4.8–5.3) | 4.0 (3.6–4.4) | <.001 |
| Environmental | 5.2 (4.3–6.1) | 4.8 (4.4–5.1) | 3.9 (3.7–4.2) | 3.2 (2.8–3.6) | <.001 |
| Emotional | 6.0 (5.2–6.9) | 5.1 (4.9–5.6) | 4.6 (4.3–5.0) | 3.9 (3.5–4.4) | <.001 |
| SGRQ domains | |||||
| Overall | 23 (15–31) | 39 (34–43) | 44 (40–47) | 55 (50–60) | <.001 |
| Symptom | 46 (32–59) | 55 (51–60) | 59 (56–63) | 70 (65–74) | <.001 |
| Activity | 26 (15–42) | 51 (44–58) | 57 (52–62) | 68 (62–74) | <.001 |
| Impact | 12 (4–21) | 27 (23–32) | 31 (27–35) | 42 (37–48) | <.001 |
| SF-36 domains | |||||
| Physical CS | 50 (43–56) | 43 (39–47) | 39 (35–42) | 31 (27–34) | <.001 |
| Mental CS | 48 (24–73) | 45 (41–49) | 44 (40–47) | 45 (40–49) | .706 |
| Spirometric values | |||||
| FEV1 (L) | 2.5 (1.9–3.0) | 2.2 (2.0–2.4) | 2.1 (1.9–2.2) | 2.0 (1.8–2.2) | .028 |
| FEV1 % predicted | 80 (71–90) | 75 (70–80) | 74 (71–78) | 71 (65–76) | .095 |
| PEFR (L/s) | 6.2 (4.9–7.5) | 5.1 (4.6–5.5) | 4.7 (4.4–5.0) | 4.4 (4.0–5.0) | .001 |
| PEFR % predicted | 88 (74–102) | 73 (67–79) | 72 (68–76) | 66 (59–72) | .005 |
CS, Component summary.