Table 2.
Differences in metabolites between children with and without asthma.
| Proposed metabolite | Single reaction monitoring (SRM) |
Controls (normalized counts/second) |
Asthma (normalized counts/second) |
Fold difference | |||
|---|---|---|---|---|---|---|---|
| Q1/Q3 | p-value | Mean | SD | Mean | SD | ||
| 2-isopropylmalic acid | 175.0/115.0 | 3.28E-22 | 19 698 | 4731 | 10 055 | 2507 | 0.51 |
| ascorbic acid | 175.0/87.0 | 8.77E-16 | 10 465 | 2115 | 5985 | 2505 | 0.57 |
| 6-phospho-d-gluconate | 275.0/97.0 | 1.15E-10 | 568 | 175 | 333 | 147 | 0.59 |
| shikimate-3-phosphate | 253.1/97.0 | 1.18E-09 | 5844 | 2548 | 2756 | 1974 | 0.47 |
| Glutathione (red) | 308.1/162.0 | 2.43E-07 | 880 | 429 | 1559 | 748 | 1.77 |
| Pyrophosphate | 176.8/158.6 | 1.17E-06 | 2237 | 631 | 1575 | 637 | 0.70 |
| hexose-phosphate | 259.0/79.0 | 8.06E-06 | 11 224 | 3026 | 15 276 | 5251 | 1.36 |
| maleic acid | 115.0/71.0 | 8.08E-06 | 26 855 | 6292 | 21 191 | 5632 | 0.79 |
| 2-hydroxy-2-methylbutanedioic acid | 147.0/85.1 | 1.10E-05 | 28 085 | 5878 | 22 817 | 5409 | 0.81 |
| Hypoxanthine | 135.0/92.0 | 1.59E-05 | 49 000 | 23 081 | 70 564 | 24 139 | 1.44 |
| d-glucarate | 209.0/85.0 | 1.92E-05 | 2770 | 857 | 2129 | 517 | 0.77 |
| 2-oxobutanoate | 101.0/57.2 | 4.91E-05 | 11 197 | 3335 | 8631 | 2622 | 0.77 |
| Methylnicotinamide | 137.0/94.0 | 6.69E-05 | 9612 | 3277 | 12 546 | 3718 | 1.31 |
| trehalose-6-phosphate | 421.0/79.0 | 0.00016 | 218 | 107 | 294 | 84 | 1.35 |