Figure 7.

(A) Gross examination and soft X-ray examination of the fibrin gel group, fibrin gel apatite-coated PLGA/HA particulate group, BMP-2-loaded fibrin gel group, and BMP-2-loaded apatite-coated PLGA/HA particulates suspended in a fibrin gel group at 8 weeks after implantation into critical-sized calvarial defects of rats. (B) Radiological defect healing at 8 weeks. Reproduced from Kim SS, Gwak SJ, Kim BS. Orthotopic bone formation by implantation of apatite-coated poly (lactide-co-glycolide)/hydroxyapatite composite particulates and bone morphogenetic protein-2. J Biomed Mater Res A. 2008;87(1):245–253.¹⁶⁹

Abbreviations: PLGA, poly(lactic-co-glycolic acid); HA, hydroxyapatite; BMP-2, bone morphogenetic protein 2; HAp, hydroxylapatite particulates.