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Identification of TMEM16A inhibitors. A. Schematic of assay. FRT cells stably expressing TMEM16A and a halide-sensitive YFP sensor were incubated for 10 min with test compound. Extracellular addition of addition of iodide and ATP results in YFP quenching whose rate is reduced by TMEM16A inhibition. B. Original fluorescence quenching curves for inhibition of TMEM16A by 10aa. C. Concentration-dependent inhibition of TMEM16A by 10aa (mean ± S.E., n=4).
