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. Author manuscript; available in PMC: 2018 Jun 8.
Published in final edited form as: J Med Chem. 2017 May 24;60(11):4626–4635. doi: 10.1021/acs.jmedchem.7b00020

Figure 4.

Figure 4

Patch-clamp studies of TMEM16A inhibition by 10bm. A. Representative currents recorded from an inside-out membrane patch. Cytosolic (bath) free Ca2+ concentration was 305 nM. Each panel of traces show superimposed membrane currents elicited at membrane potentials in the range −100 to +100 mV. Currents were recorded under control conditions, after application by perfusion of 10bm (250 nM), and after washout. B. Current-voltage relationships from the experiment shown in A. Current values were measured at the end of each voltage step. C. Summary of conductance values at +100 mV obtained from five independent experiments (***, p < 0.001 by paired t test).