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. Author manuscript; available in PMC: 2018 Jun 8.
Published in final edited form as: J Med Chem. 2017 May 24;60(11):4626–4635. doi: 10.1021/acs.jmedchem.7b00020

Figure 5.

Figure 5

Microsomal stability of 10bm and 4 in the presence of hepatic microsomes and NADPH, AND inhibition of isometric smooth muscle contractions of ex vivo mouse ileum by 10bm. A. Structure of 10bm. B. LC/MS traces showing total ion counts as a function of incubation time. C. Summary of in vitro metabolic stability shows percent of remaining compounds over time (mean ± S.E.M., n=3). D. Isometric smooth muscle contraction in mouse ileum showing suppression by 10bm. Data representative of three separate experiments.