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. 2015 Sep 28;1:15001. doi: 10.1038/npjsba.2015.1

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Copyright © 2015 The Systems Biology Institute/Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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De novo phosphoprotein networks. (a,b) Positive and negative interplay between phosphoprotein components of signaling networks as estimated by graphical network modeling of miRNA perturbation data specific to the cell lines shown. (c,d) Differences in signaling networks between cell lines with differing KRAS and BRAF mutational statuses. (e) Hive plot of the phosphoprotein links in each cell line (node) and the common links among the cell lines (edges). Inset, Venn diagram of the common links across all three cell lines. (f) Western blot analysis of the effect of the MEK inhibitor U0126 on ERK and GSK3β phosphorylation in the three cell lines. (g) Scatter plots demonstrating correlation between MEK, ERK, and GSK3β phosphorylation in The Cancer Genome Atlas (TCGA) pancancer and ovarian tumor samples.