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. 2015 Dec 10;1:15016. doi: 10.1038/npjsba.2015.16

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Copyright © 2015 The Systems Biology Institute/Macmillan Publishers Limited

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Cdc14 early anaphase release (FEAR) in cdc15Δ cells. (a) Control cells (cdc20Δ GAL-CDC20) are synchronized in metaphase by pre-simulation for 135 min in the absence of Cdc20, then Cdc20 is added back at t=0. These cells exit mitosis normally. (b) When cells lacking Cdc15 are treated the same way, Cdc14 is released only for a short time. Without MEN support, Cdc14 quickly returns to the nucleolus because, as Clb2 drops, Net1 is reactivated and Cdc14 becomes resequestered. This transient release of Cdc14 agrees well with observations shown on Figure 1b of ref. 45. MEN, mitotic exit network.