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. 2015 Sep 28;1:15005. doi: 10.1038/npjsba.2015.5

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Copyright © 2015 The Systems Biology Institute/Macmillan Publishers Limited

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Sunitinib induces glycogen accumulation and oxidative stress in patients with renal cell carcinoma. (a and b) Six patients with advanced renal cell carcinoma (RCC) who were scheduled for treatment with sunitinib were enrolled in the study. Blood samples were collected before sunitinib treatment, weekly during the first course of treatment, and every 2 weeks during the second and third courses. Sunitinib administration increased blood glycogen content (a) and serum thiobarbituric acid reactive substance (TBARS) levels (b). Each circle represents a measured value, and each horizontal line represents the mean of the measured values. ***P<0.001 versus before sunitinib treatment.