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. 2015 Sep 28;1:15005. doi: 10.1038/npjsba.2015.5

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Copyright © 2015 The Systems Biology Institute/Macmillan Publishers Limited

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Vitamin E does not impair the anticancer effects of sunitinib. (a–c) Mice subcutaneously inoculated with Lewis lung carcinoma (LLC) cells were fed a diet containing sunitinib with or without α-tocopherol nicotinate (α-TN) for 14 days, after which the pharmacological effects of sunitinib were analyzed. The effects of sunitinib on tumor regression at the site of inoculation (a) and on tumor metastasis to the lungs (b) are not impaired by co-administration of α-TN. In addition, tumor (at the site of inoculation) hemoglobin content (c) is unaffected by α-TN co-administration. Data are expressed as the mean±s.d. (n=6). ***P<0.001 versus control.