Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Mar 3;2:16002. doi: 10.1038/npjsba.2016.2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 The Systems Biology Institute/Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Overview of the PATHLINKER algorithm. Given an interactome, we identify a set of receptors and a set of TRs for a particular curated pathway (e.g., Wnt). We apply PATHLINKER to reconstruct the pathway, ranking proteins and interactions by their first occurrence in the k shortest paths from any receptor to any TR. Using the curated pathway as a ground truth, we evaluate the performance of PATHLINKER. We combine the ranked lists for multiple curated pathways to obtain an aggregate evaluation.