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. 2016 Oct 27;2:16027. doi: 10.1038/npjsba.2016.27

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Overview of the experimental outline, analyses, and clustering patterns. (a) Workflow outlining the experimental design, profiling, and bioinformatics analyses. (b) Transcriptome changes of selected genes upon vesicular stomatitis virus (VSV) infection. (c) Skewness coefficient for the distribution of fold changes based on Z score for transcriptome, proteome, and phosphoproteome for each time point after infection. (d) Venn diagram depicting the overlap of differentially expressed genes at transcriptome, proteome, and phosphoproteome levels. (e) Significantly enriched biological processes (P value⩽0.005) at transcriptome, proteome, and phosphoproteome. (f) The normalized mean expression changes for each time point after VSV infection with error bars depicting the extent of expression changes for the subset of genes associated with three representative biological processes that are significantly regulated at transcriptome/proteome/phosphoproteome. Heatmap depicts the expression changes of selected genes associated with the respective biological process.