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. 2016 Oct 27;2:16027. doi: 10.1038/npjsba.2016.27

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Pathway perturbation analysis and dynamics of RIG-I signaling pathway. (a) Scatter plot summarizing the results of the signaling pathway impact analysis of differentially regulated transcriptome, proteome, and phosphoproteome at 20 min, 3 h, and 6 h after vesicular stomatitis virus (VSV) infection, and heatmap representing the total perturbation values for signaling pathways with false discovery rate (FDR)⩽0.05 at the transcriptome/proteome/phosphoproteome level. (b) The RIG-I signaling pathway (adapted from KEGG database) overlaid with the OMICS data. Genes are marked in yellow filled rectangles. Heatmap strip on top, bottom-right, and bottom-left represent changes at transcriptome, proteome, and phosphoproteome, respectively. Data points with no available OMICS data are marked with an X. Phosphorylation sites are also marked.