Table 1.
In vitro cytotoxicity of Tf-NGO@Pt (72 hours)
| Samples | IC50 (μM)
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MG63 | HeLa | CaSki | SiHa | MCF7 | A375 | HepG2 | Chem5* | NIH3T3* | HK2* | SV-HUVC1* | |
| NGO (mg/mL) | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 |
| NGO-PEI (mg/mL) | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 | >2.0 |
| Pt complex | 132.7 | 34.4 | 35.3 | 35.8 | 29.3 | 59.8 | 55.8 | >150 | >150 | >150 | 89.6 |
| NGO-Pt-PEI | 126.3 | 30.6 | 31.2 | 29.6 | 10.2 | 54.7 | 50.2 | >150 | >150 | >150 | 92.3 |
| Tf-NGO@Pt | 110.6 | 25.2 | 25.6 | 23.4 | 6.5 | 50.2 | 46.7 | >150 | >150 | >150 | 95.8 |
Notes:
*
Chem5, NIH3T3, HK2, and SV-HUVC1 are normal cells.
Abbreviations: Tf, transferrin; NGO, nanographene oxide; PEI, polyethylenimine.