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. Author manuscript; available in PMC: 2017 Jul 19.
Published in final edited form as: Biomacromolecules. 2016 Dec 21;18(1):201–209. doi: 10.1021/acs.biomac.6b01485

Figure 1.

Figure 1

Longitudinal in vivo SPECT-CT of 111In-TNP and 111In-UNP in xenograft-bearing mice. Male athymic nude mice bearing both a PC-3 PIP (PSMA(+), red circles) and PC-3 flu (PSMA(−), yellow circles) xenograft were injected with ∼31 MBq of labeled TNP or UNP and scanned side-by-side at the indicated times. Images are scaled to the same maximum. TNP uptake at 48 h shows tumor uptake in both the PSMA(+) PC-3 PIP and PSMA(−) PC-3 flu xenografts, while both tumors in the UNP mouse remain comparatively low in uptake. After 72 h, TNP is still present along the edges of both PSMA(+) PC-3 PIP and PSMA(−) PC-3 flu xenografts and mediastinal uptake is apparent, possibly within lymphatic tissue (arrowhead). UNP uptake at 72 h remains comparatively low. By 96 h, TNP uptake is still present at the edges of both tumor types, and some UNP uptake is apparent within the PSMA(+) PC-3 PIP tumor (upper panel). Distal spleen uptake is visible within the slices and is depicted by white arrows.