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. Author manuscript; available in PMC: 2017 Jul 19.
Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):7737–7743. doi: 10.1021/jm800765e

Figure 4.

Figure 4

The hydrophobic pocket accessory to the S1 site. The dissected substrate-binding cavity of GCPII is shown in semitransparent surface representation (gray). The side chains of amino acids delineating the “accessory hydrophobic pocket” are shown in stick representation and colored cyan. The active-site Zn2+ and S1-bound Cl− are colored blue and yellow, respectively, and water molecules are represented by red spheres. Compound 4 bound to the active site is in stick representation.