Table 2.
Electrophysiological parameters and their ability to predict adverse arrhythmic events
| Category | Parameter | Studies | Events n (%) | Odds ratios (95% CI) | PPV (%) | NPV (%) | P value |
|---|---|---|---|---|---|---|---|
| Autonomic | Baroreflex sensitivity | 2 | 48/359 (13.4) | 1.98 (0.60–6.59) | 16.3 | 89.9 | 0.23 |
| Heart rate turbulence | 3 | 66/434 (15.2) | 2.57 (0.64–10.36) | 22.1 | 88.1 | 0.16 | |
| Heart rate variability | 4 | 83/630 (13.2) | 1.72 (0.80–3.73) | 16.9 | 89.7 | 0.13 | |
| Surface electrical | QRS duration & LBBB | 10 | 262/1797 (14.6) | 1.51 (1.13–2.01) | 18.5 | 87.6 | 0.01 |
| Fragmented QRS | 2 | 65/652 (10.0) | 6.73 (3.85–11.76) | 24.0 | 94.8 | <0.001 | |
| Positive SAECG | 10 | 152/1119 (13.6) | 2.11 (1.18–3.78) | 18.9 | 89.5 | 0.017 | |
| T-wave alternans | 12 | 177/1631 (10.9) | 4.66 (2.55–8.53) | 14.8 | 97.0 | <0.001 | |
| QRS-T angle | 1 | 97/455 (21.3) | 2.01 (1.22–3.31) | 25.4 | 85.5 | 0.006 | |
| Arrhythmia | Positive EPS | 15 | 146/936 (15.6) | 2.49 (1.40–4.40) | 29.2 | 86.9 | 0.004 |
| Non-sustained VT | 18 | 403/2746 (14.7) | 2.92 (2.17–3.93) | 20.7 | 90.3 | <0.001 |
Figure adapted from30 (ECG – electrocardiogram, EPS – electrophysiological study, LBBB – left bundle branch block, NPV – negative predictive value, PPV positive predictive value, VT – ventricular tachycardia).