Table 4.
Studies investigating the use of 123-metaiodobenzylguanidine scintigraphy for the prediction of adverse arrhythmic events in patients with heart failure.
| Study | N (DCM) | Inclusion criteria | Follow-up (median) | End-point | Variable | Results |
|---|---|---|---|---|---|---|
| Merlet et al (1999)68 | 112 (112) | LVEF<40% NYHA 2–4 |
27 months | SCD* | H:M ratio (continuous variable) | Low H/M predicted SCD; p=0.0015 (HR/CIs not quoted) |
| Sood et al (2013)69 | 317 (317) | LVEF<35% NYHA 2–3 |
17 months | Arrhythmic event† | SRS>8 in pts with H:M<1.6 | HR 3.3 95% CI 1.1:9.8 P=0.032 |
| ADMIRE-HF (2010)70 | 961 (327) | LVEF<35% NYHA 2–3 |
17 months | Arrhythmic event† | H:M≥1.60 | HR 0.37 95% CI: 0.16:0.85 P=0.020 |
| Boogers et al (2010)71 | 116 (30) | Referred for ICD | 23 months | Appropriate ICD therapy‡ | Late defect score >26 | HR 12.81 95% CI: 3.01–54.50 P<0.01 |
| Tamaki et al (2009)72 | 106 (51) | LVEF<40% NYHA 1–3 |
65 months | SCD* | Abnormal WR | HR 4.79 95% CI 1.55–14.76 P=0.0064 |
| Kioka et al (2007)73 | 97 (46) | LVEF<40% NYHA 1–3 |
65 months | SCD* | Abnormal WR | HR 6.13 95% CI 1.53–24.5 P<0.05 |
*
witnessed cardiac arrest, death within 1 hour after onset of symptoms or unexpected, unwitnessed death in a patient known to have been well 24 hours previously;
†
sustained VT, resuscitated cardiac arrest, appropriate ICD shock or ATP;
‡
appropriate ICD shock or ATP; CI confidence interval, H:M – heart:mediastinal ratio; HR – hazard ratio, ICD – implantable cardioverter defibrillator, LVEF – left ventricular ejection fraction, NYHA – New York Heart Association, SCD – sudden cardiac death; WR – washout rate